摘要
白细胞介素1受体相关激酶(interleukin-1 receptor-associatd kinase,IRAK)家族被认为是TLR/IL-1R信号通路中重要的信号分子。迄今为止,已发现4个IRAK家族成员,其中IRAK-1和IRAK-4有激酶活性,IRAK-2和IRAK-M无激酶活性。最近的研究发现IRAK-M参与负性调控TLR信号通路和具有天然免疫的作用。本文就IRAK-M的结构特点及在TLR信号转导的分子机制和免疫耐受中的作用进行综述。
The interleukin-1 receptor-associated kinase （IRAK） family is thought to be a type of key signal molecules in TLR/IL-1R-mediated signal pathway. So far, Four IRAK family members have been found, which consists of two active kinases, IRAK and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. In recent studies, IRAK-M has been considered to involve in negatively regulating of TLR signaling and innate immune homeostasis. This review will discuss the progress in the structure, function and molecular mechanism of TLR signaling regulation and immune tolerance of IRAK-M.
出处
《生命科学》
CSCD
北大核心
2009年第3期430-433,共4页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金(30500463)
