上消化道运动障碍与胃食管反流病相关性研究

Relative Study of Upper Gastrointestinal TracT Dysmotility and Gastroesophaeal Reflux Disease

目的分析胃食管反流病(GERD)患者的胃及胆囊运动特点,探讨胃及胆囊运动障碍在GERD发病中的作用,以期有助于临床诊断。方法应用B超对60例GERD患者和30例健康志愿者进行餐后胃及胆囊运动功能监测,并根据内镜检查结果,把GERD患者分为反流性食管炎(EE)组、非糜烂性反流病(NERD)组,然后分别比较GERD组与健康对照组以及EE组与NERD组之间的胃及胆囊运动参数。结果GERD组的胃排空指数平均值与对照组比明显降低(P<0.01),胆囊排空指数平均值与对照组比降低,但差异无统计学意义。EE组胃排空指数平均值较NERD组低,且差异具有统计学意义;两组胆囊排空指数无差异。结论胃动力障碍参与了GERD的发病。GERD患者存在的胃动力障碍以胃排空延缓为主。GERD患者未发现明显胆囊排空障碍。

Objective To observe the gastric and gall bladder motility in patients with gastroesophaeal refulx disease （GERD） , and serach the relation between gastric and gall bladder dysmotility and GERD. Methods To observed the gsstrie and gall bladder motility in 60 patients with GERD and 30 healthy volunteer by B-uhrasound. According to the result of endoscopy, the patients were divided into erosive esophagitis（EE） group and non-erosive reflux disease（NERD） group. Then compared the parameters of gastric and gall bladder motility between GERD group and healthy volunteers group, and EE or NERD group. Resuits The average value of index of gastric erupting in GERD group was lower than that in healthy volunteers group （ P 〈 0. 01 ）. The average value of index of gall bladder erupting of GERD group was lower than that in healthy volunteers group either, although the difference was not significant（ P 〉 0. 05 ）. The average value of index of gastric erupting in EE group was lower than that in NERD group（ P 〈 0. 05 ）. The difference of the average value of gall bladder emptlng between the 2 groups was not signif- icant （ P 〉 0. 05 ）. Conclusion Gastric dismotility play an important role in the progress of GERD, and delayed gastric emptying is the major type of gastric dismotility in this disease. However, the gall bladder dismotility is not relative to the progress of GERD.