输精管结扎术与前列腺癌发病风险关系的Meta分析

Vasectomy Not Associated with Prostate Cancer:A Meta-analysis

目的:评价输精管结扎术与前列腺癌发病风险的关系。方法:以"前列腺癌"、"输精管结扎术"及其同义、近义词为关键词,在CBMDisc、CMCC、CMAC、CNKI(1978年至2009年1月6日)和PubMed(1965年至2009年1月6日)等国内外数据库上进行全面检索,按文献纳入及剔除标准筛选出符合要求的文献,提取出相关数据,以RevMan4.2进行一致性检验后采取随机效应模型对纳入研究的文献进行综合定量分析,求出合并OR值及95%CI,并分层分析结扎年限<20年和≥20年与前列腺癌发病风险的OR值及95%CI。结果:共有27篇文献纳入研究,其中队列研究7篇,病例对照研究20篇,共收集研究对象252594例,其中病例20088例,对照232506例。合并OR值(95%CI)为1.10(0.97～1.24),分层分析显示结扎年限<20年和≥20年的合并OR值(95%CI)分别为0.94(0.83～1.06)和1.05(0.90～1.23)。结论:现有研究表明输精管结扎术不会增加前列腺癌的发病风险。

Objective： To evaluate the association between vasectomy and prostate cancer. Methods： We searched comprehensively the databases, CBMDise, CMCC, CMAC, CNKI （from 1978 to January 6, 2009） , and PubMed （from 1965 to January 6, 2009） using the key words ＂vasectomy＂ and ＂prostate cancer＂ , screened the retrieved literature according to the inclusion and exclusion criteria, performed a Meta-analysis with the software RevMan 4.2 after identification of the relevant data, and calculated the overall pooled OR （95% CI） as well as that of the association of prostate cancer with 〈 20 and ≥ 20 yr vasectomy. Results： A total of 20 088 eases and 232 506 controls in 27 reports （7 cohort and 20 case-control studies） were included in this investigation. The overall pooled OR （95% CI） was 1.10 （0.97-1.24）, and those of 〈20 and ≥20 yr vasectomy were0.94 （0.83-1.06） and 1.05 （0.90 - 1.23 ）, respectively. Conclusion ： No existing literature show any positive association between vasectomy and prostate cancer.