摘要
瘦素是肥胖基因的蛋白产物,参与了机体体重和能量调节、免疫调节、血管生成、炎症反应和青春期启动及生殖调节等一系列重要生理活动。瘦素发挥的不同作用与其受体(Ob-R)表达分布的时空特征相关,瘦素在睾丸内发挥着多种重要的生物学作用。本文通过综述Ob-R在大、小鼠及人类睾丸的不同细胞和不同发育阶段以及生理和病理状态下的表达和分布情况,结合已有的体外实验结果,探讨了Ob-R与睾丸功能的关系,希望能为进一步研究人类睾丸的生理发育及男性不育的病理生理机制开拓思路。
Leptin, a 167-amino acid peptidic hormone encoded by the obese gene, is known to be involved in the regulation of body fat, energy expenditure, immune function, angiogenesis, inflammatory reaction, the onset of puberty, and the regulation of reproductive function. The roles of leptin vary with different expression and distribution patterns of its receptor Ob-R. This article analyzes the biological effects of leptin and its receptor on the testis by reviewing the expression and distribution of Ob-R in different cells during different developmental stages or in different physiological and pathological states in the testis of men, mice or rats.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2009年第6期551-555,共5页
National Journal of Andrology
关键词
睾丸
瘦素
受体
分布
功能
testis
leptin
receptor
distribution
function
