依达拉奉对颅脑损伤患者血清胃泌素水平及疗效的影响

Influence of Edaravone on the level of serum gastrin and efficacy in patients with craniocerebral injury

目的观察依达拉奉对颅脑损伤患者血清胃泌素水平及疗效的影响。方法60例颅脑损伤患者随机分为依达拉奉组及地塞米松组，并给予相应的治疗。检测治疗后1d、3d、5d、7d血清胃泌素水平；治疗1个月后依据神经功能缺损程度评分（NDS）及Barthel指数（BI）评价疗效。结果依达拉奉组治疗后第3d血清胃泌素水平开始下降，第5d、7d恢复正常；地塞米松组第5d开始下降，第7d仍高于正常水平；两组间治疗后3d、5d及7d时血清胃泌素水平差异有统计学意义（P〈0．05～0．01）。治疗1个月后依达拉奉组NDS及BI明显优于地塞米松组（均P〈0.01）；总有效率（83．3％）显著高于地塞米松组（63．3％）（P〈0．05）。结论依达拉奉能有效降低颅脑损伤患者血清胃泌素水平，改善神经功能缺损，提高疗效。

Objective To observe the influence of Edaravone on the level of serum gastrin and efficacy in patients with eranioeerebral injury. Methods 60 patients with eraniocerebral injury were randomly divided into Edaravone group （30 eases ） and Dexamethasone group （30 eases ）. Then each group reeeived corresponding treatment. The level of serum gastrin was detected at 1st d, 3rd d, 5th d and 7th d after treatment. The curative effect was evaluated based on the neuroligieal deficit score （ NDS ） and Barthel index （ BI ） one month after treatment. Results The level of serum gastrin in Edaravone group began to decrease at the 3rd d after treatment, at the 5th d and 7th d became to normal value. While, in Dexamethasone group 5th d after treatment, the level of serum gastrin began to decrease, but at the 7th d was still significantly higher than the normal value. The levels of serum gastim at 3 d,5 d and 7 d after treatment were significant difference between the two groups （ P 〈 0. 05 - 0.01 ）. And one month after treatment ,the scores of NDS and BI in Edaravone group were better than those in Dexamethasone group（ all P 〈 0. 01 ）. The total effective rate in Edaravone group （83.3%） was significant higher than Dexamethasone group （63.3%） （P 〈 0. 05 ）. Conclusion Edaravone can effeetive reduete the level of serum gastrin of patients with eranioeerebral injury, improve the neuroligical deficit, and increase therapeutic effect.