摘要
ABCG2转运蛋白是与肿瘤多药耐药有关的新的药物排出泵,具有抑制消化道吸收某些外源性物质,参与形成胎盘屏障等生理功能。通过研究ABCG2转运蛋白的功能及其转运机制,寻找低毒有效的ABCG2调节剂是提高化学治疗疗效的重要方法。研究ABCG2基因多态性对于改善药物疗效,提高药物的生物利用度,避免和降低药物的不良反应,指导临床抗肿瘤个体化治疗具有重要意义。近年来关于ABCG2转运蛋白的研究取得了较大的进展,本文综述了相关领域的研究结果。
ABCG2 is a new muhidrug resistance-related transmembrane transporter. It plays a role in formation of protection barrier of the fetal placenta and in the inhibition of the transporting exogenous chemicals through the epithelium of gastrointestinal tract. The research of physiological functions and the transport mechanism of ABCG2 providing the search for innocuous and effective modulator of ABCG2 is an important route for improving the efficiency of cancer chemotherapy. The research of ABCG2 gene polymorphism may promote the efficiency and increase drug bioavailability with simultaneously lowering adverse reactions and providing significant guidance for individual antitumor chemotherapy clinically. In recent years, great progress has been achieved in the study of ABCG2. This paper comprehends the fruitful outcomes concerning the correlative fields.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2009年第6期405-410,共6页
Chinese Journal of New Drugs and Clinical Remedies
