复发性鼻咽癌三维适形放射治疗的疗效分析

Effect analysis of 3-dimensional conformal radiotherapy on recurrent nasopharyngeal carcinoma

目的分析复发性鼻咽癌三维适形放射治疗的疗效及影响疗效的因素。方法56例复发性鼻咽癌接受三维适形放射治疗,鼻咽部剂量50～70Gy/36～52d(中位64Gy/44d)。结果全组病例随访3年以上。3年总生存率、无瘤生存率和鼻咽部局部控制率分别为48.2%、44.6%和53.6%。复发间隔时间>2年和复发临床分期T_2期者,3年生存率和局部控制率高(P<0.05);再程放疗剂量≥60Gy者,3年生存率和局部控制率优于<60Gy。结论三维适形放射治疗是复发性鼻咽癌有效的治疗手段,其复发间隔时间、复发临床分期和再程放疗剂量是影响预后的因素。

Objective To investigate the effect and prognostic factors of 3-dimensional conformal radiotherapy （3-DCRT） on recurrent nasopharyngeal carcinoma （NPC）. Methods 56 cases of recurrent NPC were treated by 3-DCRT. The radiation dose was 50 - 70Gy for 36 -52d, with the median of 64Gy for 44d. Results The follow-up time for all cases was over three years. The 3-year survival rate,tumor-free survival rate and nasopharyngeal local control rate were 48.2% ,44. 6% and 53.6% ,respectively. The cases with recurrence time longer than two years and the eases at stage T2 had a better 3-year survival rate and local control rate. The cases treated with radiation dose over 60Gy had a better 3-year survival rate and local control rate than that with dose less than 60Gy. Conclusions 3-DCRT is an effective treatment for recurrent NPC. The recurrent time,clinical stage and radiation dose are the prognostic factors.