摘要
促皮质素对甲醛引起大鼠脊髓ｃｆｏｓ表达的影响及受体分析黎海蒂１，李希成，阮怀珍（第三军医大学生理教研室，重庆４０００３８，中国）１ＣｏｒｅｓｐｏｎｄｅｎｃｅｔｏＰｒｏｆＬＩＨａｉＤｉ．Ｐｈｎ８６２３６８７５２２６９．Ｆａｘ８６２３６５３...
AIM: To study the effect of corticotropin (Cor) on c fos expression induced by formalin in spinal cord of rat and the role of receptors. METHODS: Using immunohistochemistry and adrenalectomy. RESULTS: Cor inhibited the formalin evoked c fos expression in rat spinal cord in a dose dependent manner. No obvious effect was seen by ip Cor 10 U·kg -1 , but 25 U·kg -1 reduced the evoked c fos expression, that was blocked by phentolamine, naloxone, or verapamil, but not much changed by adrenalectomy. CONCLUSION: The formalin evoked c fos expression of rat spinal cord was suppressed by Cor through the α adrenergic receptors, opiate receptors and calcium, but no relation to adrenal glands.
出处
《中国药理学报》
CSCD
1998年第4期394-396,共3页
Acta Pharmacologica Sinica
关键词
促皮质素
C-FOS
甲醛
脊髓
免疫组化
corticotropin
proto oncogene proteins c fos
formaldehyde
phentolamine
naloxone
verapamil
spinal cord
immunohistochemistry
