L-精氨酸及谷氨酸对未成年小鼠学习与记忆功能的影响

Ettect of L-arginine and glutamate on learning and memory of mice

研究了不同剂量的Ｌ精氨酸（ＬＡｒｇ）以及与谷氨酸（Ｇｌｕ）合用时对神经系统（海马区）的影响，以及ＮＯ介导谷氨酸的神经毒作用。通过观察小鼠的学习与记忆的过程，各组与正常对照组之间的被动回避反应的结果显示其嗜暗反应的潜伏期在大剂量ＬＡｒｇ与ＬＡｒｇ及Ｇｌｕ合用组明显延长，同时观察病理切片显示海马区的神经元细胞减少，神经胶质细胞增多等方面有不同程度的变化，ＮＯ作用具有浓度依赖性，大剂量有神经毒作用。

The effects of different doses of both L-arginine and L-arginine plus glutamate on the nervous system were studied by observation of mices learning and memory abilityThe results of tested and control groups showed that L-arginine in high concentration of Lariginine plus glutamate might effect mices learning and memory abiliby and the abnormal pathomorphological changes appearedMoreover in high concentrations NO could effect mices learning and memory ability