LEEP治疗宫颈上皮内瘤变60例临床分析

LEEP treatment of cervical intraepithelial neoplasia 60 cases

目的探讨宫颈环形电切除术（loop electrosurgical excision procedure，LEEP）在宫颈上皮内瘤变（cervicalintraepithelialneoplasia，CIN）的诊断及治疗中的应用价值。方法对2007年10月至2008年10月在我院就诊的60例应用LEEP术诊治的CIN患者的临床资料进行回顾，并对比分析阴道镜下活检病理结果与LEEP术后病理结果；同时观察手术时间、术中出血量、术后疗效。结果60例患者行LEEP术前、术后病理诊断级别相符48例，符合率为80％，升高3例（5％），降低9例（15％）；手术时间为（5．2±1．4）min，术中出血量为（8．3±3．6）ml。结论LEEP术不仅有疗效好、操作简单、安全、术后并发症少、可提供完整的病理标本的优点，且能提高宫颈癌的早期诊断率及降低宫颈早期浸润癌的漏诊率，是诊断及治疗CIN病变的一种非常有价值的方法。

Objective To discuss the diagnosis and the treatment value of loop electrosurgical excision procedure （LEEP） applied in the cervical intraepithelial neoplasia （CIN）. Methods The clinical data resulting from 60 inpatients being diagnosed CIN from Oct. 2007 to Oct. 2008 was analyzed retrospectively. The comparative analysis of pathologic findings was made after the operation of LEEP and vaginoscope biopsy. At the same time, the time of operation, the volume of bleeding and postoperative outcome was observed. Results The diagnosis grade of 48 examples was in line with that of 60 examples applied with LEEP technique before and after pathological diagnosis and the the coincidence rate was 80%. The pathological grade of 3 examples （5%） elevated and that of 9 examples （15%） reduced. The operation time was （5.2±1.4）min and the volume of bleeding was （8.3±3.6 ）ml during the surgery. Conclusion It was effect, security, safe and feasible of LEEP technique that eould take out of the pathology specimen eom- pletely and could enhance early diagnosis rate and reduce the misdiagnosis rate of cervical cancer. So it was valuable method of diagno- ses and treatment of CIN.