NMDA受体拮抗剂氯胺酮对体表炎症痛反应的影响

EFFECTS OF NMDA RECEPTOR ANTAGONIST KETAMINE ON PAIN RESPONSE OF CUTANEOUS INFLAMMATION

大鼠左足用鹿角菜致炎，痛阈显著降低后，腹腔注射ＮＭＤＡ受体的非竞争性拮抗剂氯胺酮，痛阈显著升高；鹿角菜与氯胺酮同时给药组的痛阈幅值升高更为明显而持久。结果提示，ＮＭＤＡ受体参与炎症痛的形成和发展；提前给予其拮抗剂氯胺酮可提高镇痛效应。

Pain threshold (PT) in left foot of rats was significantly increased when a non competitive NMDA receptor antagonist, ketamine, was intraperitoneally injected after the PT was significantly decreased by carrageenin injection; The increase in value of PT became even more apparent and prolonged if both carrageenin and ketamine were injected simultaneously. The results indicate that NMDA receptor seems to be involved in the formation and development of inflammatory pain; The analgesic effect of its antagonist, ketamine, might be improved and the development of inflammatory pain in skin slowed down if the ketamine is given prior to carrageenin injection.