利多卡因预防异丙酚静脉注射痛

LIDOCAINE FOR PREVENTING INJECTION PAIN OF PROPOFOL

目的：探讨利多卡因预防异丙酚静脉注射痛的最佳剂量。方法：１２０例ＡＳＡⅠ～Ⅱ级择期手术患者，随机分为例数相等的四组，Ⅰ组：异丙酚；Ⅱ组：异丙酚＋利多卡因０．１ｍｇｋｇ；Ⅲ组：异丙酚＋利多卡因０．３ｍｇｋｇ；Ⅳ组：异丙酚＋利多卡因０．５ｍｇｋｇ。异丙酚的用量均为２．５ｍｇｋｇ。结果：Ⅱ、Ⅲ、Ⅳ组异丙酚静脉注射痛的发生率明显低于Ⅰ组（Ｐ＜０．０１～０．０５），而Ⅱ、Ⅲ、Ⅳ组间异丙酚静脉注射痛的发生率无显著性差异（Ｐ＞０．０５）。结论：利多卡因可预防异丙酚所致的注射痛，剂量为０．１ｍｇｋｇ时，效果与０．３ｍｇｋｇ和０．

Aim: To study the effect of lidocaine for preventing injection pain of propofol. Methed: 120 patients (ASA Ⅰ～Ⅱ) were randomly divided into four groups, Group Ⅰ:Propofol: Group Ⅱ: Propofol + Lidocaine 0.1mgkg;Group Ⅲ: Profofol + Lidocaine 0.3mgkg; Gropu Ⅳ: Propofol + Lidocaine 0.5mgkg. The dosage of propofol was 2.5mgkg in all four groups. Results: The incidence of injection pain of propofol in group Ⅱ, Ⅲ and Ⅳ was significantly lower than that in group Ⅰ (P<0.01～0.05); But incidence of injection pain of propofol were not significantly different among groups Ⅱ,Ⅲ and Ⅳ (P>0.05).Couclusion: Lidocaine can prevent injection pain of propofol. A dose of 0.1mgkg providd the same analgesic effect as that of 0.3 and 0.5mgkg.