云南省丁丙诺啡片与安定、盐酸异丙嗪等多种药物混合滥用的潜力分析

ABUSING POTENTIAL OF COMBINED USE OF BUPRENORPHINE WITH DIAZEPAM AND PROMETHAZINE IN YUNNAN

目的:分析云南省丁丙诺啡舌下片(简称丁丙诺啡片)与安定注射液、盐酸异丙嗪注射液等多种药物混合注射滥用(简称丁丙诺啡片多药滥用)的潜力,为政府主管部门的防治工作提供参考依据。方法:采用自行设计的《丁丙诺啡使用情况调查问卷》收集丁丙诺啡片多药滥用者的基本情况和多药滥用情况;采用《视觉类比量表》调查滥用者滥用的主观感受等,并将结果与单独海洛因滥用者和单独丁丙诺啡片滥用者进行比较。结果:丁丙诺啡片与安定注射液、盐酸异丙嗪注射液混合注射滥用者开始使用频率比较与经常使用频率有统计学意义(P=0.001),随着滥用时间的延长,丁丙诺啡片每日使用次数及每次使用量在增加;丁丙诺啡片多药滥用可以减少丁丙诺啡片的用量。66.9%的丁丙诺啡片多药滥用者在减少或停止使用后出现过戒断症状。海洛因滥用者、丁丙诺啡片单一滥用者、丁丙诺啡片多药滥用者的视觉类比量表(VAS)测量分值存在差异(P<0.01)。丁丙诺啡片多药滥用自1992年开始出现以来,滥用人数逐年增多。结论:丁丙诺啡片与安定、盐酸异丙嗪等混合滥用具有滥用潜力,存在流行趋势。建议相关部门进一步加强对丁丙诺啡片、安定等精神药物的处方管理及监管,以防止这些药品的流弊或非法销售,造成更大范围的滥用。

Objective：To analyze the abusing potential of combined use of buprenorphine with, diazepam and promethazine in Yunnan. Methods： An investigation was conducted among users of buprenorphine plus diazepam and promethazine with a selfdesigned questionnaire to collect data concerning multiple drug use and with Visual Analogue Scale （VAS） to get the information of the experience from using the drugs, the results of which were compared among heroin, buprenorphine and the combined drug users. Results： There was statistical significance （P = 0. 001 ）between the frequency of initial use and the frequency of regular use in multiple drug users, the frequency and quantity of buprenorphine use increased as the time of abuse went on. 66.9% of the combined users experienced withdrawal symptoms when reducing the dose or discontinuing drug use. Significant differences were observed among the users using heroin alone, buprenorphine alone and comhined users by VAS （P 〈 0. 01 ）. Since buprenorphine plus diazepam and promethazine abuse started in 1992, the number of abusers has been increasing year by year. Conclusion： Buprenorphine plus diazepam and promethazine can produce abusing potential of the drugs. We suggest that the administration of these drugs should be enhanced and monitoring of such drugs should be conducted to avoid their abuse.