气相色谱法测定替普瑞酮胶囊的含量

GC determination of terprenone capsules

目的:建立气相色谱法测定替普瑞酮含量的方法。方法:采用DB-FFAP弹性石英毛细管柱(30m×0.32mm×0.25μm);FID检测器;色谱条件:柱温为200℃;进样口温度为250℃;检测器温度为250℃;分流进样,分流比为1∶10。结果:替普瑞酮在0.1～10.0mg·mL-1范围内线性关系良好(r=0.9999,n=7);替普瑞酮的回收率(n=9)为98.0%～102.0%。结论:本测定方法准确、灵敏、专属性高,可作为替普瑞酮胶囊的含量测定方法。

Objective：To establish a GC method to determine the content of the terprenone capsules. Method：Using DB - FFAP capillary column（30 m × 0. 32 mm × 0.25 μm）and FID under the following chromatography condition：column temperature was set at 200℃, injector and detector temperature were both set at 250℃, split ratio was 1： 10. Result： The calibration curves showed a good linearity over the range of 0. 1 - 10. 0 mg· mL^-1（r = 0. 9999, n = 7 ）. The recovery （ n = 9 ） of terprenone was 102. 0%. Conclusion： The method is specific, accurate, sensitive and suitable for the determination of terprenone capsules.