286株凝固酶阴性葡萄球菌临床分布及耐药性分析

Analysis of clinical distribution and drug-resistance of 286 strains of coagulase negative Staphylococcus

目的：通过分析凝固酶阴性葡萄球菌（CNS）临床分布及耐药情况,为临床合理用药提供依据。方法：采用ATB-Expression细菌鉴定及药敏系统对2006年1月～2009年1月门诊及住院患者各类标本分离到的CNS进行的鉴定和药敏实验进行回顾性分析。结果：共检出286株11种CNS菌,广泛存在于14类临床标本中;其中,呼吸道、泌尿道标本中CNS的分离率最高为32.4%、23.2%。以表皮葡萄球菌、溶血葡萄球菌和缓慢葡萄球菌为主。其耐药性以青霉素、红霉素、苯唑西林最高,分别为96%、94%、81%;对氯洁霉素、第二代喹诺酮、左氟沙星耐药性次之,也大于70%;对呋西地酸、替考拉宁、米诺环素、喹奴普叮-达福普叮耐药率低,小于10%,未检出对万古霉素耐药菌株。结论：临床应关注CNS的感染,控制该类感染并应积极进行病原菌学监测,根据药敏结果选用抗菌药物,延缓其耐药性的产生和蔓延。

Objective：To analyze the distribution and drug resistance of coagulase negative Staphylococcus （CNS） to provide the teference for rational use of agents, nethods：CNS isolated from inpatients from January, 2006 to January, 2009 were identified with ATB expression microbial identification and drug sensitivity system. Results：A total of 286 strains were isolated, including 11 kinds of CNS. They exist in 14 specimen. The highest rate of isolation in auatomy tract and urinary tract stood at 32.4%, 23.2% most CNS were Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus lentus. The drug - resistant rate to penicillin, erythromycin and oxacillin stood at 96%, 94%, 81%. The drug -resistan to clindamycin, second generation quinolones, levofloxacin was more than 70%. The drug- resistant to vancomycin was zero. Conclusion： The clinic should attach importance to the infection and monitor pathogenic detection. The doctors should also use antimicrobial agents in aecordience with the drug sensitivity system and to postpone the producing and spread of drug resistance.