医院耐甲氧西林金黄色葡萄球菌感染现状的分析

Analysis of methicillin-resistant staphylococcus aureus infection in hospital

目的：了解耐甲氧西林金黄色葡萄球菌（MRSA）的医院感染现状,指导临床合理选用抗生素,预防爆发流行,为临床防治提供依据。方法：对我院2005年1月～2006年12月期间,门诊和住院病人的标本中分离的179株金黄色葡萄球菌进行了MRSA感染监测,并对逐个暴露因素进行单因素卡方分析和Logistic多元回归分析,筛选出MRSA感染的危险因素。结果：MRSA总分离率为70.9%,其中,2005年检出率为60%,2006年检出率为79%;MRSA感染部位以呼吸道为主,感染科室以神经外科、ICU科、普外科为主;住院时间、侵袭性操作、使用抗生素、合并感染、入住神经外科等5个因素与MRSA感染有关联。结论：MRSA的分离率呈逐年上升趋势,侵袭性操作、抗生素的使用和神经外科是MRSA感染的3个危险因素。

Objective：To study the current situation that hospital onset of infection caused by methicillin -resistant staphylococcus aureus （MRSA） in the hospital, benefit clinical to select antibiotic for use reasonably, and prevent MRSA epidemic outbreak. Approach the evidence for clinical prevention and cure. Methods： The research was done to detect MRSA in 179 samples from patients in clinic and in hospital which was infected by staphylococcus aureus from January 2005 to December 2006. The available data were analyzed by Chi - square test and multiple Logistic regression model. Results：The results shows that the total isolating rate is 70. 9% by the three methods. Among them, the isolating rate in 2005 is 60% , and the isolating rate in 2006 is 79%. The respiratory tract is the major part in MRSA infection; while the high infection division is the neurosurgery, ICU, and the general surgery. The five risk factors of MRSA infection were long - term hospitalization, invasive operation , using antibiotics, complicated infection and hospitalization in neurosurgery. Conclusion： The tendency of MRSA isolating rate is to rise year by year. The invasive operation, the antibiotic use and the neurosurgery are three risk factors related to MRSA.