重型乙型肝炎与IL-6关系的研究

STUDY ON CORRELATION BETWEEN IL-6 AND SEVERE HEPATITIS B

探讨白细胞介素6（IL-6）在重型乙型肝炎发病机制中的作用。方法：采用生物活性检测方法对重型乙型肝炎患者IL-6活性进行研究。结呆：发现重型乙型肝炎组IL-6活性（197±19）显著高于慢性肝炎中度组（173±27）、急黄肝组（172±37）及正常对照组（105±24）。结论：提示机体内IL-6分泌调节紊乱在介导重型乙型肝炎肝细胞坏死方面可能具有重要作用。

Objective: to examine the action of nterleukin 6(IL-6) on immuno pathogenesis of Severe Hepatitis B(SHB). Methods: Level of IL-6 produced by peripheral blood mononuclear cells was investigated in SHB. Results: It was found that the activity of IL-6 in SHB group (197±19 ) was significantly higher than that in chronic active hepatitis group (173±37), and normal control group (105±24). Conclusion: The results implied that perturbation of secreting and immunoregulation in IL-6 might play an important role in causing hepatocyte necrosis in SHB. the follow-up observation of some patients we found that activity of IL-6 gradually decreased to that .of normal control group in convalescence of SHB. It was thus inferred that dynamic change of IL-6 might reflect the condition of the disease