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拉米夫定治疗B、B+C、C基因型慢性病毒性乙型肝炎患者的临床疗效观察 被引量：4

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摘要 目的观察B、B+C、C基因型慢性病毒性乙型肝炎病人对拉米夫定抗病毒治疗的临床疗效。方法30例B型慢性病毒性乙型肝炎病人、15例B+C型及50例C型慢性病毒性肝炎病人同时给予拉米夫定100mg,每天1次,疗程1年,观察血清病毒学指标、肝功能变化。结果B型慢性病毒性乙型肝炎病人治疗后HBV-DNA阴转率、HBeAg血清转换率及ALT复常率均显著高于B+C及C型慢性乙型肝炎病人,差异均有统计学意义(P<0.05)。结论C及B+C基因型慢性乙型肝炎病人的拉米夫定治疗的临床疗效较B基因型差,慢性乙型肝炎病人对拉米夫定抗病毒的免疫应答与基因型有关。
作者 方军伟 顾美芬
机构地区 仙居县中医院
出处 《中国预防医学杂志》 CAS 2009年第6期532-533,共2页 Chinese Preventive Medicine
关键词 慢性病毒性肝炎 乙型 基因型 拉米夫定 疗效
分类号 R512.62 [医药卫生—内科学] R373.21 [医药卫生—病原生物学]
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参考文献8

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共引文献21

同被引文献42

  • 1杨光,崔金环,陈姝,司建华,谭家驹.乙型肝炎病毒逆向点杂交基因分型法建立及应用[J].中华肝脏病杂志,2004,12(11):677-680. 被引量：9
  • 2谢琴秀,许家璋,李平,杨志国,孟运运,李旭.江苏地区乙型肝炎病毒基因分型及其临床意义[J].疾病控制杂志,2005,9(2):171-173. 被引量：42
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引证文献4

二级引证文献9

中国预防医学杂志
2009年 第6期

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