摘要
为了探讨D二聚体(Ddimer,DD)与心、脑血管疾病的关系,采用ELISA双抗体夹心法对72例心血管病人、51例脑血管病人和71例健康对照,进行了血浆D二聚体的测定。在年龄、性别等因素均衡的基础上,显示心、脑血管病例组的D二聚体含量分别为116mg/L和083mg/L,均显著高于对照组(043mg/L)。进一步将两病例组分为心肌梗塞、非心梗性冠心病、脑梗塞和脑出血亚型后,发现除了脑出血组外,其余三组的DD水平仍显著高于对照(P<005)。结果揭示D二聚体的检测在心、脑血管疾病发生中具有重要诊断价值,其含量可作为疗效观察和预后判断的指标之一。此外,根据D二聚体水平鉴别脑梗塞和脑出血的实际意义值得深入研究。
To find out the relationship between D dimer (DD)and cardiovascular and cerebrovascular diseases,the plasma concentration of D dimer was measured in 72 patients with cardiovascular disease,51 with cerebrovascular disease and 71 health controls by using the sandwith ELISA.On the basis of matching factors in year、 sex etc,the level of DD in cardiovascular and cerebrovascular diseases was 1 16 mg/L and 0 83 mg/L respectively,and was higher than that in controls (0 43 mg/L).Then,the investingation on the myocardial infarction,other coronary heart disease,cerebral infarction and cerebral hemorrhage showed that the DD in preceding three diseases were higher ( P < 0.05 ),while in cerebral haemorrhage did not show significant higher ( P >0.05).The result suggests that the DD detection is valuable for the diagnosis of cardiovascular and cerebrovascular diseases.The level of D dimer could make an important mark of treatment effect for the two kinds of diseases.The differentiation of the subtypes of cerebrovascular diseases according to the level of D dimer needs to make a thorough study.
出处
《山西医科大学学报》
CAS
1998年第2期111-113,共3页
Journal of Shanxi Medical University
关键词
心血管疾病
脑血管疾病
D-二聚体
cardiovascular diseases
cerebrovascular disorders
D dimer