老年2型糖尿病合并血管并发症患者C-反应蛋白与游离脂肪酸的关系

The Relationship between C-Reactive Proteins and Free Fatty Acids Level in Elder Type 2 Diabetic Patients with Angiopathy

目的研究老年2型糖尿病和老年2型糖尿病合并血管并发症患者C-反应蛋白(CRP)和游离脂肪酸(FFAs)的变化及相关性,探讨C-反应蛋白和游离脂肪酸在老年糖尿病合并血管并发症发生中的作用。方法用免疫比浊法检测51例老年2型糖尿病伴有血管并发症组,65例老年2型糖尿病无血管并发症组及62例正常对照组血清C-反应蛋白。用酶法测定这三组患者的血清FFA、TG、TC、BS、BUN和HDL-C的浓度。并将C-反应蛋白与FFAs浓度和血糖作相关分析。结果老年2型糖尿病血清CRP、FFAs、TG、TC、BS和BUN较正常对照组比较差异有显著性(P<0.05)。2型糖尿病伴有血管并发症组患者CRP与FFAs呈正相关(r=0.490,P<0.05)。无并发症组患者的FFA和CRP呈正相关(r=0.112,P<0.05)。结论老年2型糖尿病合并血管并发症患者血清中CRP和FFAs浓度升高,CRP与FFAs一样可作为非特异性血管并发症标志物。

Objective To investigate the changes of C-reactive proteins count and free fatty acids（FFAs）level in elder type 2 diabetic patients with angiopathy and explore the role of CRP and FFAs in the pathogenesis of diabetic angiopathy. Methods The number of CRP and concentration of FFAs were detemined in 51 diabetic patients without angiopathy, 62 diabetic patients with angiopathy and 65 healthy subjects. Results Both CRP and FFAs concentration in the diabetic patients were obviously higher than those in healthy subjects（P〈 0.05）. And in diabetic patients with angiopathy were also significantly higher than those in diabetic patients without one（P〈 0.05）. CRP was positively correlated with FFAs in diabetic patients with angiopathy. Conclusion Both CRP and FFAs concentration increase in elder type 2 diabetic patients with angiopathy .CRP may be a biological mark for angiopathy as FFAs.