肺支原体肺炎患儿肌红蛋白、肌钙蛋白Ⅰ和肌酸激酶同工酶的检测

The Detection of Myoglobin,Cardliac Troponin-Ⅰ and Creatine Kinase-MB in Children with Mycoplasmal Pneumonia

目的检测并比较肺支原体肺炎(MPP)患儿治疗前后血清中肌红蛋白(Mb)、肌钙蛋白Ⅰ(CTn-I)和肌酸激酶同工酶(CK-MB)的含量,以探讨其在MPP合并心肌损害诊治中的意义。方法抽取MPP合并心肌损伤组(55例)患儿急性期和恢复期的静脉血,测定其血清中Mb、cTn-I和CK-MB的含量并比较其变化,以55例健康儿童做为对照组。结果MPP合并心肌损伤组患儿急性期血清中Mb、cTn-I和CK-MB的含量显著高于健康对照组(P<0.01)。MPP合并心肌损伤组患儿恢复期血清Mb、cTn-Ⅰ和CK-MB的含量与急性期相比明显下降(P<0.01),但仍高于对照组(P<0.05)。结论MPP患儿有部分患者急性期有不同程度的心肌损害。

Objective To detect and compare the change of level of myoglobin（Mb）, cardliac troponin I（cTn-I） and creatine kinase-MB （CK-MB） in children with acute mycoplasmal pneumonia combine with injury of cardiac muscle, in order to discuss the signifance in the diagnosis of disease. Methods The content of Mb,cTn-I and CK-MB in serum were measured and the change were compared in 55 cases MPP combined with injury of cardiac muscle, during acute and recovery phase, and 55 normal children were served as control group. Results The value of Mb,cTn-I and CK-MB in MPP combined with injury of cardiac muscle group were sighificantlly higher than in control group in the serum of acute phase （P〈 0.01 ）. And the content of Mb,cTn-I and CK-MB were descended in recovery phase and were significant lower than that of acute phase, but still higher than the control group（P 〈 0.05）, in MPP combined with injury of cardiac muscle group （P 〈 0.01 ）. Conclusion Children with mycoplasmal pneumonia may combine myocardial injures,and Mb,cTn-I and CK-MB are sensitive parameters to diagnose the injure of cardiac muscle.