奥美拉唑联合莫沙必利治疗反流性食管炎的近期疗效

The Curative Effect of Omeprajole Combined with Mosapride in Treatment of Reflux Esophagitis

目的观察奥美拉唑联合莫沙必利缓解胃食管反流症状和治疗反流性食管炎的疗效。方法106例反流性食管炎病人,其中治疗组36例用奥美拉唑和莫沙必利,对照1组35例用奥美拉唑;对照2组35例用莫沙必利,观察治疗前及治疗后2、4、8周的临床症状改善和治疗8周的内镜变化。结果用药2周、4周时,治疗组症状好转与对照组相比,差异有统计学意义(P<0.05),用药8周结束时,治疗组症状改善明显优于对照组1和2组(P<0.05),内镜8周复查治疗组、对照组1和2组食管粘膜病损愈合率分别为86.1%、62.9%和57.1%,差异有统计学意义(P<0.05)。结论奥美拉唑和莫沙必利联合用药较单一用药治疗反流性食管类疗效更好。

Objective To observe the curative effect that treating and mitigating reflux esophgitis with omeprajole and mosapride. Methods one hundred and six patients were divided into three groups. The first group（36 case） were treated with omeprajole and mosaprid. The second group（35 sides） were treated with omeprajole. The third group（35 sides） were treated with mosapride. The change in symptom and endoscope before and after treatment were observed. Results After treated for two week and four week,the first group was better than second and third group. There was significant difference between first group and second group or third group（P〈0.05）. When eight week, the symptom had been improved obviously in first group（P〈 0.05 ）. Esophageal mucosa erosion was coalesce,the percentage was 86.1%, 62.9%, 57.1%, there was significant difference（P 〈 0.05 ）. Conclusion Omeprazole combined with mosapride is better in curing reflux esophagitis.