子宫内膜癌癌周内膜病理学特征与临床分析

The Relationship between the Pathologic Features of the Uninvolved Endometrium and Prognosis in Postmenopausal Carcinoma

目的研究绝经后子宫内膜癌癌周内膜的病理学特征与临床及预后的关系。方法根据癌周内膜的组织学表现分为增生型和萎缩型两组,对23例子宫内膜癌患者的临床与病理特点和5年随访结果进行回顾性分析。结果癌周内膜呈增生型的子宫内膜癌患者伴发高血压、肥胖、糖耐量异常、子宫内膜增生过长史的机率显著高于癌周内膜呈萎缩型的子宫内膜癌患者(P<0.01);癌周内膜呈萎缩型者较增生型者呈低分化倾向及深肌层浸润(P<0.01);5年生存率,癌周内膜呈增生型子宫内膜癌患者为87.5%,萎缩型为40.0%(P<0.05)。结论子宫内膜癌癌周内膜不同的病理学特征与预后相关,癌周内膜呈增生型者的预后好于萎缩型。

Objective To investigate the relationship between the pathologic features of the uninvolved endometrium and prognosisin postmenopausal endometrial carcinoma. Methods The clinicopathologic features of 23 cases ot endometrial carcinoma were analyzed retrospectively. Results According to the proliferative uninvolved endometeium（PUE） were more much related with the clinical risk factors than those of atrophic uninvolved endometrium（AUE）（P〈 0.01）. Aue cases had much worse grade,much deeper myometrial invasion（P〈0.01）. The overall 5 year survival rate lwas 87.5%in the PUE and 40.0% in the AUE cases（P〈0.05）. Conclusion The histopathologic types of the uninvolved endometrium were related to the prognosis of the patients with endometrial carcinoma. The patients with proliferative uninvolved endometrium had better prognosis than those with atrophic uninvolved endometrium.