风湿性二尖瓣狭窄患者肺功能与血流动力学相关分析

Correlative Study on Pulmonary Function and Hemodynamics in Patients With Rheumatic Mitral Stenosis

目的：评价风湿性二尖瓣狭窄（ＭＳ）患者心肺功能的相互关系。方法：对３２例ＭＳ患者进行肺功能和右心导管检查。统计处理采用典型相关分析。结果：小气道功能指标最大呼气中段流速、５０％肺活量用力呼气流速和２５％肺活量用力呼气流速代表主要肺功能改变，肺小动脉阻力、肺动脉压、肺小动脉嵌顿压代表主要血流动力学改变；对血流动力学变化较敏感的肺功能指标是潮气量、５０％肺活量用力呼气流速和２５％肺活量用力呼气流速比值、肺活量、最大呼气中段流速；对肺功能变化较敏感的血流动力学指标是心输出量、肺血管阻力、肺小动脉嵌顿压。结论：血流动力学与肺功能之间有显著的相关关系。

? Objective:To evaluate the correlation of cardiac and pulmonary functions in patients with rheumatic mitral stenosis(MS). Methods:Pulmonary function and cardiac catheterization were performed in 32 patients with MS. Results:Abnormalities of main pulmonary function were reflected from the parameters of small airway function including maximal midexpiratory flow rate(MMF),flow at 50 and 25 percents of the forced expired vital capacity(50,25).Changes of main hemodynamic data were reflected from the parameters of pulmonary arteriolar resistance,pulmonary artery pressure and pulmonary artery wedge pressure(PAWP).The tidal volume,50/25,vital capacity and MMF were more sensitive to changes of hemodynamics.The cardiac output,pulmonary vascular resistance and PAWP were more sensitive to changes of pulmonary function. Conclusion:The cause and effect correlation seems present between pulmonary function and hemodynamics.