原发性高血压基础血流和高流量状态下血管内皮因子变化及与高血压的关系

Relationship between Endothelial Factors and High Blood Pressure under Conditions of Baseline and Hyperemia in Essential Hypertension Subjects

以正常血压者和原发性高血压患者为对象,比较两组在基础血流下内皮松弛因子(NO)和ET水平及内皮依赖性血管扩张改变。结果发现:1.基础状态下NO水平分别为(72.7±44.4)和(63.6±41.5)μg/L(t=1.00,P>0.05)。2.ET水平分别为(46.4±18.0)和(62.4±29.7)ng/L(t=-2.84,P<0.01)。3.高血压患者内皮依赖性血管扩张明显低于正常血压者(0.28±2.95)％对(5.39±3.96)％,t=7.23,P<0.01。结论认为:原发性高血压患者ET和NO水平在基础状态下处于不平衡状态,高ET水平是维持异常增高血压机制之一。NO生成或释放缺陷可能是导致高血压的另一重要机制。

Baseline serum nitric oxide(NO) .plasma endothelin(ET) ,and hyperemia endothelium-dependent vasodilation were measured in normotensive and essential hypertensive subjects. The results showed that (l)NO levels were similar in two groups (72. 7 ± 44.4 and 63. 6 ± 41. 5)μg/L respectively,t = 1. 00, P>0. 05; (2)ET was significantly higher in essential hypertensive subjects than that in normotensive ones (62. 4 ± 29. 7 vs 46. 4 ± 18. 0)ng/L,t= -2. 84,P<0. 01; (3)The ability of endothelium-dependent vasodilation was stronger in former group than in latter one (5. 39%±3-96% vs 0. 28% ± 2. 95%,t = 7. 23,P<0. 01). It could be concluded that:there is an imbalance between ET and NO in hypertensive subjects, high ET level is one of the mechanisms maintaining high blood pressure. Impairment of NO synthesis and release may be another mechanism in hypertension.