氨氯地平对36例高血压病人左心室舒张功能的影响

The effect of amlodipine on left ventricular diastolic function in 36 hypertensive patients.

目的：探讨氨氯地平对高血压患者左心室舒张功能的影响。方法：采用自身对照开放试验方法，观察氨氯地平对３６例高血压患者左心室舒张功能的影响，治疗前后作超声多普勒测量和二尖瓣血流速度变化分析，并进行对照分析。结果：３６例高血压治疗８周后，显效３０例，无效２例，总有效率为９４％。超声多普勒对照检查显示，总外周阻力（ＴＰＲ）、心肌重量（ＬＶｍａｓｓ）、室间隔舒张末期厚度（ＩＶＳｄ）下降，峰值充盈速度Ａ、峰值速度Ａ／峰值速度Ｅ比值下降，左心室舒张早期快速充盈速度（ＤＣ）上升，差异均具有显著性（Ｐ＜０．０５）。结论：氨氯地平在降压的同时，能有效改善左心室舒张功能。

Objective: To study the effect of amlodipine on left ventricular diastolic function in hypertensive patients. Methods: A self control open clinical trial was carried out to inspect the effect of amlodipine on left ventricular diastolic function in patients with hypertension. Ultrasonic scanning and mitral blood speed analysis were performed in all 36 patients and results were compared before and after amlodipine treatment. Results: After 8 weeks of treatment with amlodipine (5 mg/d), 30 patines achieved excellent therapeutic effective, 2 patients had no response. The total effective rate was 94% Ultrasonic scanning comparison indicated that TPR, LV mass, IVSd A and A/E indexes were all decreased, while DC increased. Significant differences among these indexes existed before and after treatment (P<005). Conclusion: Amlodipine, could not only decreases blood pressure, but could also improve left ventricular diastolic function at the same time.