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蛋白酶激活受体2在类风湿关节炎中的作用研究进展

Role of protease activated receptor-2 in rheumatoid arthritis:recent progress
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摘要 蛋白酶激活受体2(protea seactivated receptor-2,PAR-2)是G蛋白偶联受体,主要是由肥大细胞表达,并可被胰酶、类胰蛋白酶激活,然后可导致肥大细胞去颗粒化而引起炎症。类风湿关节炎发生的本质过程可能就是通过激活肥大细胞上表达的PAR-2起作用。 Protease activated receptor-2 （PAR-2） is a G-protein-coupled receptor. Recent studies indicate that PAR-2 is mainly expressed in leukocytes and activated by panereatin and （or） tryptase,which subsequently induces inflammation through degranulation of leukocytes. Activation of PAR-2 in leukocytes is possibly involved in the pathogenesis of rheumatoid arthritis.
作者 刘随意 阳青松 贾益鑫 戴生明
机构地区 第二军医大学长海医院风湿免疫科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2009年第6期725-726,共2页 Academic Journal of Second Military Medical University
基金 国家自然科学基金(30872338)~~
关键词 蛋白酶激活受体2 类风湿关节炎 肥大细胞 类胰蛋白酶类 protease activated receptor2 rheumatoid arthritis mast cells tryptases
分类号 R593.22 [医药卫生—内科学]
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参考文献15

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二级参考文献33

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第二军医大学学报
2009年 第6期

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