强力宁对肝硬化患者血清生化指标改变的探讨

Effects of glycyrrhizan on the serum levels of some biochemical indexes in patients with liver cirrhosis

目的：观察强力宁对肝硬化患者的治疗作用。方法：对４０例肝硬化患者应用强力宁治疗，８０ｍｌ／ｄ，共４周，并于治疗前后检测超氧化物歧化酶（ＳＯＤ）、谷光甘肽过氧化酶（ＧＳＨＰｘ）、还原性谷光甘肽（ＧＳＨ）、脂质过氧化物（ＬＰＯ）、丙氨酸转移酶（ＡＬＴ）和胆红素。结果：治疗前ＳＯＤ、ＧＳＨＰｘ明显低于正常人，ＬＰＯ高于正常人，治疗后ＳＯＤ、ＧＳＨＰＸ增高，ＬＰＯ和ＡＬＴ胆红素下降。

Objective:To observe the curative effect of glycyrrhizan as an anti lipid peroxidation drug on patients with liver cirrhosis Methods:Forty patients with liver cirrhosis received glycyrrhizan injection(80 ml/d),and serum SOD,LPO,GSH Px,GSH,ALT and bilirubin were measured before treatment and after 4 weeks Results:SOD and GSH Px activties were decreased and LPO were increased in patients with liver cirrhosis.After treatment,SOD and GSH Px were increased and LPO,ALT and bilirubin were decreased Conclusion:It is considered that glycyrrlizan is an anti lipid peroxidation drug