纳米羟基磷灰石／聚氨酯复合生物膜制备与表征

Preparation and Characterization of Nano-Hydroxyapatite/Polyurethane Composite Bio-film

通过异氰酸根和羟基的反应,采用溶剂蒸发的方法,合成了13Wt%纳米羟基磷灰石/聚氨酯(HA/PU)复合诱导骨再生膜,经XRDI、R、TG、SEM、吸水率、表面接触角、拉伸和燃烧试验的测试,对膜材的结构和特性进行了表征。结果表明,纳米羟基磷灰石/聚氨酯复合膜,有良好的均一性,有机和无机之间有很好复合,加入纳米磷灰石形成的类骨磷灰石,具有良好的骨诱导性,HA/PU复合膜具有良好的吸水性和力学性能,且溶剂蒸发后形成的表面孔隙有利于细胞的新陈代谢。HA/PU复合膜在组织工程上是一类很好的骨诱导再生膜。

Through Hydroxyl （-OH） reacting with isocyanate group （-NCO）, 13 Wt% nano-hydroxyapatite（n- HA）/polyurethane（PU） composite guided bone regeneration membrane was synthesized by use of solvent evaporation method. Its surface character was analyzed by XRD, IR, TG, contact angle, water absorption, elongation and combustion test and SEM. The results indicate that nano-HA/PU has good homogeneity, the interface between the inorganic mineral and organic polymer is optimized to create proper combination; that n-HA crystals are similar to the apatite crystals in natural bone, HA/PU composite membrane has good hydrophilicity mechanical behavior; and that many pores are observed on the membrane which help cells＂ metabolism. So the HA/PU composite membrane, thus prepared, has the potential for use in guided bone regeneration and tissue engineering.