血液代用品功能评价参数的研究进展

Research Progress in Estimating Parameters of Blood Substitute Function

全世界范围内血源紧张、病毒污染等问题推动了血液代用品的研究。各种修饰血红蛋白、氟碳乳剂、血红蛋白微囊等技术迅速发展,其中一些已经形成规模化制备工艺。但是,对于血液代用品目前没有完整的评价体系,全面评估血液代用品产品仍较困难。本文根据国内外血液代用品的研究现状和最新进展,重点从血液代用品的评价角度出发,探讨血液代用品的评价参数,围绕血液代用品的理化性质、有效性与安全性、保存条件等方面进行了综述。

The shortage of healthy blood resource and the problem of virus infection have urged the study of blood substitute. The technologies of modified hemoglobin, perfluorocarbons and Hb-vesicles have been developing quickly, and some of which have already been formed into large-scale preparation and production. However, there is no completed evaluation system for the blood substitute at present, and it is still hard to estimate the function of blood substitute completely. This article takes the evaluation of the blood substitute as a key point, discusses the evaluation parameters of blood substitute, and presents the physical and chemical property, the availability and safety as well as the preservation condition of the blood substitute. The data concerned are based on the studies in China and abroad and referred to the latest progress all over the world.