阿奇霉素治疗小儿呼吸道感染68例疗效观察

Observation on therapeutic effect of azithromycin in treating respiratory infection in 68 children

目的观察阿奇霉素治疗儿童呼吸道感染的治疗效果。方法将138例呼吸道感染患儿随机分成治疗组和对照组,治疗组(n=68):静滴阿奇霉素10mg/(kg·d),连用5～7d,对照组(n=70):静滴红霉素15～30mg/(kg·d),观察两组治疗前后的症状、体征,胸片及不良反应,比较两组的恢复时间及痊愈率、有效率、不良反应发生率。结果治疗组的退热时间、止咳时间、罗音消失时间短于对照组(P<0.05),痊愈率、有效率均高于对照组(P<0.05),不良反应发生率低于对照组(P<0.05)。结论阿奇霉素治疗儿童呼吸道感染疗效可靠,不良反应少,值得推广。

[Objective] To observe the therapeutic effect of azithromycin in the treatment of children respiratory infeetion.[Methods] 138 children with respiratory infection were randomly divided into two groups： 68 children of experiment group was administered of azithromycin by intravenous drip infusion, 10 mg/kg.d for from 5 to 7 days; 70 children of control group was given of illotyein by intravenous drip infusion, 15 - 30 mg/kg .d for from 5 to 7 days. Meanwhile, symptoms, physical signs, chest-X-ray photographs and adverse effects in the two groups were observed and recorded. The recovery time, recovery rate, effective rate and the incidence rate of adverse effect in the two groups were compared. [Results] The pyretolysis time, cough-stopping time and rattle extinction time in experiment group were shorter than those in control group . （P 〈0.05）. The recovery rate and effective rate in experiment group were higher than those in control group （P〈0.05）, and the incidence rate of adverse effect in experiment group was lower than that in control group （P〈0.05）. [Conclusion] Azithromyein could be widely used in the treatment of children respiratory infection because of its reliable curative effect and less adverse effect.