氟伐他汀对缺血性脑卒中患者的疗效观察及护理措施

Effect and nursing main points of Fluvastatin on patients with cerebral arterial thrombosis

目的观察不同剂量氟伐他汀对缺血性脑卒中患者的治疗效果并初步总结治疗中的护理措施。方法将85例缺血性脑卒中患者随机分为3组，组①为空白组，组②为常规剂量治疗组，组③为大剂量强化治疗组，进行相关的治疗和护理。于治疗前及治疗4周、12周、24周检测血脂；治疗前和治疗24周时，用德国SEQUOIAS-512型B超测定颈动脉内膜-中层厚度（IMT）记录治疗中出现的副作用等进行比较。结果患者治疗4周、12周、24周血脂试验发现，两个试验组中的LDL、TC、TG下降与空白组比较均有统计学意义（P〈0．05）；在治疗24周后，两个试验组可使颈动脉内膜-中层厚度减少（P〈0．05）；而且，氟伐他汀的副作用较少，3组间的差异没有统计学意义（P〉0．05）。结论不同剂量氟伐他汀对缺血性脑卒中患者的疗效明显不同，越大剂量的氟伐他汀对缺血性脑卒中患者的LDL～L、TC降低作用越明显、对颈动脉粥样硬化发展的抑制作用就越大，且副作用未见增加。良好的护理，能使患者保持较好的用药依从性、及早发现药物的副作用，从而保证治疗的顺利进行，促进患者早日康复。

Objective To explore the effect and nursing main points of fluvastatin on the patients with cerebral arterial thrombosis. Methods Eighty-five patients with cerebral arterial thrombosis were randomly divided into three groups. Group Ⅰwas the negative control group. Group Ⅱ was the conventional-dose therapy group and group Ⅲ was the high-dose therapy group. Each group was treated with related therapy and care. The blood lipids in all groups were tested before the treatment, 4 weeks, 12 weeks and 24 weeks after the treatment; the carotid intima-media thickness （IMT） were measured by the Germany SEQUOIAS-512-B ultra machine before the treatment and 24 weeks after the treatment; At the same time, the side effects offluvastatin were recorded. Results The results of blood lipid tests showed that the LDL, TC and TG in two treated groups were significantly decreased compared to negative control group （P〈0.05）. After treated for 24 weeks, the carotid intima-media thickness （IMT） in two treated groups were significantly reduced （P〈0.05）; the side effects offluvastatin were infrequent and there was no significant different among the three groups （P〉0.05）. Conclusions The effects of different doses of fluvastatin on cerebral arterial thrombosis were significantly different. With the dose of fluvastatin increased, the serum LDL-L and TC reduced more obvious and the inhibition on carotid atherosclerosis shows more obvious, and the side effects did not increased.