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河南地区96例非综合征性唇腭裂患者TGF-α基因TaqⅠ位点多态性观察

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摘要 目的探讨转化生长因子α(TGF-α)基因TaqⅠ位点多态性与河南地区汉族人群非综合征性唇腭裂(NSCL/P)的关系。方法采用聚合酶链反应结合限制性片段长度多态性(PCR-RFLPs)对96例NSCL/P患者(NSCL/P组)和43例健康人(对照组)进行TGFα基因TaqⅠ位点基因型检测。结果NSCL/P组和对照组均扩增出178 bp(C1)和174 bp(C2)两种等位基因。NSCL/P组唇裂合并腭裂组和对照组上述两种等位基因频数相比P<0.05;NSCL/P组中按有无环境不利因素影响分组差异亦有统计学意义,P<0.05。结论TGF-α基因TaqⅠ位点多态性与河南地区汉族人群较严重型NSCL/P的发生有一定相关性。。
作者 周水勇 翟晓梅
机构地区 郑州大学第一附属医院
出处 《山东医药》 CAS 北大核心 2009年第22期98-99,共2页 Shandong Medical Journal
关键词 唇裂 腭裂 转化生长因子α基因 等位基因 基因多态性
分类号 R782.2 [医药卫生—口腔医学]
  • 相关文献

参考文献12

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二级参考文献56

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山东医药
2009年 第22期

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