超分子材料环糊精与布洛芬包合的热力学测定

Mensuration on the thermodynamic property of ibuprofen by inclusion complexation with supramolecular cyclodextrin

考察超分子材料环糊精(β-环糊精和羟丙基-β-环糊精)与布洛芬的包合作用及包合过程热力学参数的变化,探讨包合作用的机理和驱动力。采用相溶解度法研究环糊精对布洛芬的包合作用、增溶作用及包合过程中热力学参数的变化。结果表明,2种环糊精与布洛芬包合反应的吉布斯自由能变化(ΔG)、焓变(ΔH)和熵变(ΔS)均为负值。形成包合物后,布洛芬的溶解度显著增加,羟丙基-β-环糊精对布洛芬的增溶作用强于β-环糊精,稳定常数也高于布洛芬-β-环糊精包合物。2种环糊精在常温常压下可以自发形成包合物,包合过程为放热反应,低温有利于包合物的形成和稳定。与β-环糊精相比,羟丙基-β-环糊精对布洛芬的包合作用更好。

Our objectives are to study the inclusion effects and the thermodynamic parameter changes of the supramolecular materials （β-CD and HP-β-CD） on ibuprofen, and to illustrate the mechanism and drivingpower through the inclusion reaction. The phase solubility method is used to study the soluble effects of the supramolecular materials on ibuprofen and the changes of thermodynamic parameters in the complexation. Thermodynamic parameters △G, △H and △S in the complexations give negative values. The solubility is improved when ibuprofen is complexed with HP-β-CD or β-CD, the solubility enhancement and the stability constant of ibuprofen using HP-β-CD are higher than those of ibuprofen using β-CD. The results show that the inclusion complexes of BF-β-CD and BF-HP-β-CD can form spontaneously along with the release of heat. Lower temperature is a benefit to the formation and the stability of the inclusion complexes. Complexation of ibuprofen by HP-β-CD is much easier to realize than that by β-CD.