孕中期铅暴露对婴儿神经行为发育影响的研究

Effects of Lead Exposure of Pregnancy to Neuro-Behavioral Development of Infants

目的观察孕中期低水平铅暴露对新生儿神经行为发育的影响。方法选择2006～2007年,在广州市天河区妇幼保健院采用配对方法对40例已检测了孕中期血铅水平的产妇所生新生儿进行了新生儿20项行为神经发育评分(NABA),并与其母亲的孕中期血铅水平进行相关分析,以孕中期血铅水平0.28μmol/L、0.32μmol/L、0.38μmol/L(第25、第50、第75百分位)为界点,分为相对高、低铅组,进行新生儿神经行为发育评分比较。结果在分界点0.32μmol/L时,两组的总分评分开始出现显著性差异(P<0.01)。结论孕妇孕中期的铅暴露,即使在0.32μmol/L的水平,也可能对胎儿期的神经行为发育产生不良影响。

Objective To explore the effects of low- level Pb exposure during pregnancy on neuro- behavioral development of infants. Methods Forty infants were selected and their mother＇ s blood Pb levels in pregnant in second trimester were determined in 2006 - 2007. The neuro - bebavioral cognitive performance of infants were evaluated by Neonatal Behavioral Neurological Assessment（NABA）. Related analysis were made with blood lead level and nearo- behavioral development scores with pregnancy, by the Pb lead levels of O. 28μmol/L, 0. 32μmol/L, 0.38μmol/L as cutoff values, they were divided into high and low blood Pb level groups and t - test were made. Results There was a significant difference in NABA between high and low blood Pb levels groups. With pregnant in second trimester blood Pb level of 0.32μmol/L as cutoff values. There was a very significant difference in NBNA and behavioral ability between high and low blood Pb level groups. Conclusion Lower level Pb exposure （0.32μmol/L） during pregnancy can have harm- ful effects on infants development and can also cause adverse effects on neonatal neuro - behavioral development.