男性不育症患者精浆化学成份分析

Analysis of chemical components in seminal plasma of infertility male patients

目的为了探讨男性不育症患者的发病机理。方法通过检测20例对照组(生育组)与140例观察组(不育组)精浆中的果糖、锌、酸性磷酸酶、中性α-葡糖苷酶、弹性硬蛋白酶、LDH-X、顶体酶,综合分析两组精浆中的化学成分变化。结果不育症组精浆中的果糖、锌、中性α-葡糖苷酶、顶体酶每次射精含量都显著低于生育组(P<0.01);酸性磷酸酶、LDH-X每次射精含量稍低于生育组,但无统计学意义(P>0.01);而不育组弹性硬蛋白酶浓度明显高于生育组(P<0.01)。结论精浆中的果糖、锌、酸性磷酸酶、中性α-葡糖苷酶、弹性硬蛋白酶、LDH-X、顶体酶浓度可以用来综合评估男性患者的生育能力。

Objective To investigate etiopathogenesis of male infertility patients. Methods The level of fructose, zinc, acid phosphatase, neutro-α-suerosidase,elastase,lactate dehydrogenase isoenzyme X and acrosomal enzyme in 30 fertile patients （control group ） and 97 infertile male patients （observation group） were detected. Results The total amount per ejaculation of fructose,zinc, neutro-α-sucrosidase and acrosomal enzyme in seminal plasma of infertile group were significant lower than that of revile group （P〈0.01）. The total amount per ejaculation of acid phosphatase ,neutro-α-sucrosidase,actate dehydrogenase isoenzyme X in seminal plasma of infertile group were slightly lower than that of fertile group （P〉0.01）. Moreover,the concentration of elastase in seminal plasma of infertile group was obviously higher than that of fertile group（P〈 0.01 ）. Conclusion The concentration of fructose,zinc,acid phosphatase,neutro -α-sucrosidase,elastase,lactate dehydrogenase isoenzyme X and acrosomal enzyme in seminal plasma can be applied to evaluate the fertility of male patient.