自体造血干细胞回输治疗Ⅰ型糖尿病2例

A new method of type 1 diabetes treatment:T lymphocytic series clearance and autologous hematopoietic stem cell transplantation(2 cases analysis)

目的观察采用自体造血干细胞回输治疗Ⅰ型糖尿病的临床疗效。方法提取自体造血干细胞后,行T淋巴系统清除,再行干细胞回输,重建T淋巴系统,以清除原免疫系统对胰岛细胞的自身免疫反应,恢复胰岛细胞功能。结果2例患儿分别于干细胞回输后第14天、第20天停用胰岛素,安全出院。随访7个月,各项检查指标均正常。结论T淋巴系统清除和自体造血干细胞重建治疗为临床治疗Ⅰ型糖尿病提供了一种新方法,近期疗效好。

Objective To analyze the safety and effect of T lymphocytic series clearance and autologous hematopoietic stem cell transplantation （AHSCT） for type 1 diabetes （T1D）. Methods Two newly diagnosed T1D patients were managed by a low dose immuno-suppression regimen followed by AHSCT. Results In the two cases, insulin injection was stopped at 14 days and 20 days respectively after AHSCT, and discharged safely. In 7-month follow-up, their blood glucose level was normal without insulin. Conclusion The clinical outcome showed that low-dose T lymphocytic series clearance and AHSCT were performed safely in two small patients with prolonged insulin independence.