非那雄胺联合抗生素治疗血精症30例

Clinical research of Finasteride in treating hemospermia 30 cases

目的观察非那雄胺治疗血精症的临床作用并初步探讨其作用机制。方法将血精症患者56例，随机分为2组，其中对照组26例单用抗生素治疗1个月，治疗组30例采用非那雄胺和抗生素联合用药治疗1个月，并在治疗前后检测患者精液中血管内皮生长因子（VEGF）。结果对照组15例血精消失（15／26，57．7％），治疗组28例血精消失（28／30，93．3％），两组结果比较差异有统计学意义，治疗后VEGF的变化在两组病例间差异有统计学意义。结论非那雄胺联合抗生素对血精症具有更好的治疗作用，其机制可能与非那雄胺抑制VEGF的合成、微血管的形成有关。

Objective To evaluate the efficiency of Finasteride in treating inflammatory hemospermia and approach the mechanism of action. Methods 56 cases of hemospermia were randomly divided into two groups. The experimental group （ n = 30） was treated with Finasteride combined with antibiotic for 1 month, while the control group（ n = 26） was treated only with antibiotics for 1 month. The expression of VEGF in sperma was detected by enzyme linked immunosorbent assay （ELISA） in pretherapy and post-treatment. Results Hemospermia disappeared in 28 eases of experiment group（28/30, 93.3% ） and in 17 cases of control group（ 15/30, 57.7% ）, with significant difference. The expression of VEGF degrade in post-treatment. Conclusions Hemospermia can be treated more effective with finastefide combined with antibiotics. The mechanisms may be associated with Finas- teride can reduce VEGF synthesis and inhibit the microvaseular formation.