A-A大鼠模型足肿胀针灸方案优选的实验研究

Empirical study of optimization of acupuncture and moxibustion scheme on foot swelling in A-A rats models

目的优选A-A大鼠足肿胀模型针灸治疗方案,分析优选方案获效机制。方法以氟氏完全佐剂诱导的足肿胀A-A大鼠为观察对象,应用正交设计法对影响疗效的因素进行方案优选。结果采用火针局部和整体配穴可获得最佳消肿率和抑制病理进展。结论①针灸治疗类风湿关节炎(RA)有肯定的临床疗效,其能缓解RA的局部症状,减轻关节肿胀。②针灸对RA的治疗尤以火针疗效为最佳,艾灸疗效较好,局部与整体配穴具有协同意义。把握针刺最佳时机对提高RA的临床疗效尤为重要。

Objective It is to optimize the acupuncture and moxibustion scheme on foot swelling in A - A rats and to analyze the mechanism of its therapeutic effect. Methods A- A rats of foot swelling induced by Freund＇s complete adjuvant were observational object. The factor of influencing curative effect was scheme optimized with the orthogonal design. Results fire needle local and global coordination of acupoints could obtain the best subsiding swelling rate and inhibit pathological progress. Conclusion （1）Acupuncture has affirmative effect on rheumatoid arthritis （RA）. It can alleviate local symptoms of RA and joint swelling. （2）Fire needle is the best scheme in RA treatment, moxibustion has better curative effect. Local and global coordination of acupoints has synergetic significance. It is all the more important to grasp the best time of acupuncture on enhancing the clinical curative effect of RA.