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Numb在肿瘤发生中的作用机制 被引量：3

Advances in Studies of Numb in Tumorigenesis
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摘要 细胞内多基因表达异常是恶性肿瘤发生发展的基础，相关研究越来越多地集中在关键基因的探索．近年来发现的Numb蛋白在肿瘤形成、浸润与转移中的作用受到越来越多的关注。作为一种重要的发育分子．Numb是不对称分裂决定因子，参与神经前体细胞定向分化过程，并在非对称性分裂中对细胞分裂起关键调节作用。目前证实，Numb能调节细胞对分化信号的识别能力，在调控细胞生长分化、组织更新及稳定细胞内环境中发挥重要作用。目前在许多肿瘤细胞中发现Numb基因表达异常．表明Numb在肿瘤的发生发展中起着重要作用。本文就Numb的结构特性．及其与肿瘤发生可能有关的机制等方面研究作一综述。
作者 谢蟪旭 王萍 李龙江
机构地区 四川大学口腔疾病国家重点实验室
出处 《口腔颌面外科杂志》 CAS 2009年第3期206-209,共4页 Journal of Oral and Maxillofacial Surgery
基金 国家级大学生创新实验计划
关键词 Numb蛋白 NOTCH P53 肿瘤发生 Numb protein Notch p53 tumorigenesis
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

  • 1Rhyu MS, Jan LY, Jan YN. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells[J]. Cell, 1994,76(3):477-491.
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  • 6吴剑,李龙江.miRNAs在头颈肿瘤中的研究进展[J].口腔颌面外科杂志,2008,18(3):206-209. 被引量：3
  • 7Maiorano E, Favia G, Pete S, et al. Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas[J]. Int J Immunopathol Pharmacol, 2007,20(4):779- 789.
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二级参考文献31

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共引文献12

同被引文献51

  • 1陈小君,谢幸,陈怀增.细胞分裂方式及其发生机制研究进展[J].医学分子生物学杂志,2005,2(6):470-473. 被引量：1
  • 2金力,郎景和,王友芳,程雪梅.高危人类乳头状病毒负荷与宫颈上皮内瘤变的分级关系[J].生殖与避孕,2006,26(7):422-425. 被引量：39
  • 3尤克.三维适形放射治疗肝癌18例疗效观察[J].中国临床保健杂志,2007,10(1):78-79. 被引量：4
  • 4Gulino A, Di - Marcotullio L, Screpanti I. The multiple functions of Numb. Exp Cell Res,2010,316(6) :900 ~906.
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  • 6Pirinen RT, Hirvikoski P, Johansson RT, et al. Reduced expression of α - catenin, β - catenin, and γ- catenin is associated with high cell proliferative activity and poor differentiation in nonsmall eell lung cancer. J Clin Pathol,2001,54 :391 395.
  • 7Hasegawa T, Yokoyama R, Matsuno Y, et al. Prognostic significance of histologic grade and nuclear expression of beta - catenin in synovial sarcoma. Hum Patho1,2001,32 :257 ~ 263.
  • 8Mc - Gill MA, Mc - Glade CJ. Mammalian numb proteins promote Notchl receptor ubiquitination and degradation of the Notchl intracellular domain. J Biol Chem,2003,278 (25) :23196 ~ 23203.
  • 9Katoh M, Katoh M. NUMB is a break of WNT - Notch sign'Ming cycle. Int J Mol Med,2006,18(3) :517 -521.
  • 10Maiorano E, Favia G,Fece S,et al, Prognostic implications of NUMB immunoreactivity in salivary gland carcinomas, Int J Immunopathol Pharmacol,2007,20(4) :779 -789.

引证文献3

二级引证文献11

口腔颌面外科杂志
2009年 第3期

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