Nrf2对正常细胞和肿瘤细胞的微环境调控研究进展

Regulation of the Microenvironment of Normal and Cancer Cell by Nrf2

正常细胞需要面对各种各样的微环境损害,它们通过多种机制应对有毒或致癌物质的损伤,其中最重要的细胞防御机制是通过转录因子Nrf2调节的。Nrf2介导的细胞保护反应能够保护多种器官或组织,Nrf2的激活意味着对抗包括肿瘤和炎症反应等多种人类疾病,而肿瘤细胞的微环境远远比正常细胞复杂,因此Nrf2的激活对于肿瘤细胞抵御治疗、促进生长意义重大。

Since normal ceils constantly encounter various microenvironmental insults, they have evolved defense mechanisms to cope with toxicant- and carcinogen-induced oxidative stress or electrophiles..One of the most important cellular defense mechanisms against oxidative stress or electrophiles is mediated by the transcription factor Nrf2. Since this Nrf2-dependent cellular defense response is able to protect multi-organs or multi-tissues, activation of Nrf2 has been implicated in conferring protection against many human diseases, including cancer, inflammation, and so on. Moreover, the microenviroment of cancer cell is more complex, so the activation of Nrf2 is of great importance for the resistance to cancer cells and growth.