配合物{[Co(HFlu)_2Cl_2]·2C_2H_5OH}_n的合成、结构及体外抗真菌活性

Synthesis, Crystal Structures and In Vitro Anti-fungal Activities of a New Cobalt(II) Coordination Complexes of Fluconazol

新合成了1种钴-氟康唑配合物{[Co(HFlu)2Cl2]·2C2H5OH}n,利用X-射线单晶衍射仪等对配合物进行了结构分析,并研究了该配合物的体外抗真菌活性,标题化合物对丝状真菌的抗菌效果明显优于氟康唑,对酵母菌的体外抗真菌活性与氟康唑相当,

A new polymeric Cobalt （II）-fluconazole complexes：{[Co（HFlu）2Cl2】·2C2H5OH}n was synthesized and structurally characterized by X-ray single crystal diffractometer. The anti-fungaI effects of the complexes were studied. The title complexes antifungal effects against filamentous fungi were more better than fluconazole itself, while the same effects against yeasts.