L-抗坏血酸硬脂酸酯的合成条件探索

Study on Synthesis Condition of L-ascorbyl Stearate

文章对L-抗坏血酸硬脂酸酯的最佳合成条件进行探索。通过各种不同的实验条件得出最佳合成条件为:抗坏血酸比硬脂酸甲酯为1︰1.3(摩尔比),催化剂浓硫酸比(抗坏血酸+硬脂酸甲酯)为1︰0.10(摩尔比),反应温度24℃,反应时间24h。在此条件下可获得总产率为77%的抗坏血酸硬脂酸酯。考察了以硬脂酸甲酯和L-抗坏血酸为原料,通过酯交换法合成L-抗坏血酸硬脂酸酯的最佳合成条件。文章对L-抗坏血酸硬脂酸酯的最佳合成条件进行探索。通过各种不同的实验条件得出最佳合成条件为:抗坏血酸比硬脂酸甲酯为1︰1.3(摩尔比),催化剂浓硫酸比(抗坏血酸+硬脂酸甲酯)为1︰0.10(摩尔比),反应温度24℃,反应时间24h。在此条件下可获得总产率为77%的抗坏血酸硬脂酸酯。考察了以硬脂酸甲酯和L-抗坏血酸为原料,通过酯交换法合成L-抗坏血酸硬脂酸酯的最佳合成条件。

With the raw material of L-ascorbic acid and methyl stearate, the synthesis of L-ascorbyl stearate was studied by transesterification. The effects of reaction temperature, reaction time, ratio of reactant and amount of concentrated sulfuric acid on the transesterification were investigated. The experiment results showed that 77 % yield can be obtained under the following optimum synthetic conditions： molar ratio of L-ascorbic acid to methyl stearate ofl ： 1.3, reaction time of 24 h, reaction temperature of 24 ℃ and molar ratio of concentrated sulfuric acid to L-ascorbic acid and methyl stearate of 1 ： 0.10. The infrared spectrum andantioxidant effects of the product were also studied. L-ascorbyl stearate was synthesized by the transesterification of L-ascorbic acid with methyl stearate usingconcentrated sulfuric acid as both solvent and catalyst.