腹腔持续热化疗治疗卵巢癌腹水的疗效与Ca125的相关性研究

A Study on Therapeutic Effect of Continuous Intraperitoneal thermochemotherapy on Ascetic Fluid and Its Correlation with Ca125

目的:研究腹腔持续热化疗对晚期卵巢癌腹水患者血清Ca125水平变化与评估疗效的关系。方法:对132例卵巢癌腹水患者随机分成两组,腹腔持续热化疗组与对照组,均静脉滴注紫杉醇175mg/m^((2)),d1,腹腔持续热化疗组70例:放腹水后通过恒温系统腹腔持续循环灌注入腹温度为44～45℃生理盐水2000～2500ml,1小时,循环液中加入顺铂20mg,循环放水后直接腹腔保留顺铂30mg。对照组62例:放腹水后灌注顺铂50mg。两组均隔天1次,共3次,3周为1周期,共2～4周期。治疗后4周、3个月、6个月年分别观察腹水变化及测血清Ca125值。结果:腹腔持续热化疗组总有效率85.7%,对照组总有效率54.8%,两组比较有显著性差异(P<0.01)。结论:腹腔持续热化疗治疗晚期卵巢癌腹水的疗效较好,血清Ca125水平明显下降,对Ca125水平影响显著。

Objective：To research the changes of the plasma level of Cancer antigen 125（Ca125） in advanced ovarian cancer patients administered continuous intraperitoneal thermochemotherapy and its role playing in assessment of therapeutic effect. Method： a total of 132 ovarian cancer patients were divided into two groups randomly-continuous intraperitoneal thermochemotherapy group （ with 70 subjects） and controlling group （with 62 patients）, and all the subjects were dripped paclitaxel 175mg/m^2,dl intravenously. In the former group after paracentesis, 2000 to 2500 ml normal saline with the temperature of 44-45℃ was perfused into abdominal cavity continuously by constant temperature system, meanwhile one hour after paracentesis 20 mg cisplatin was administered intravenously, and after the drainage of peritoneal normal saline 50 mg cisplatin was injected into it. In the latter group, however, intraperitoneal injection of 30mg eisplatin only after aseitic fluid drainage. The procedures mentioned above performed once every other day in both groups, three times a week for 2 to 4 treatment duration （three weeks a treatment duration）. The ascitic fluid changes and plasma Ca125 was detected at the fourth week, the third month and sixth month after treatment. Result： The total effective rate is 85.7 % in thermochemotherapy group, and is 54.8% in controlling group, and there is a significant difference between them （P〈0.01）. Conclusion： continuous intraperitoneal thermochemotherapy has a better effect in treating advanced ovarian cancer, with the plasma level of Ca125 decreased significantly, and it has an obviously influence on Ca 125 level.