门冬氨酸鸟氨酸治疗急性酒精中毒的临床研究

Study of Naloxone-L-Ornithine-L-Axpartate Injection in Treatment of Acute Alcoholism

目的观察门冬氨酸鸟氨酸联合纳络酮注射液治疗急性酒精中毒的疗效。方法82例急性酒精中毒患者随机分为治疗组39例和对照组43例。治疗组给予纳洛酮和门冬氨酸鸟氨酸注射液治疗;对照组给予纳洛酮治疗。比较两组的临床疗效和兴奋及共济失调症状消失时间、神志清醒时间以及肝功能损害情况。结果①两组治愈率无明显差异(P>0.05);②两组轻中度中毒者兴奋及共济失调症状消失时间比较无明显差异(P>0.05);③两组重度中毒者比较,治疗组神志清醒时间短于对照组(P<0.05),治疗组肝脏损害减轻明显(P<0.05)。结论纳洛酮联合门冬氨酸鸟氨酸注射液治疗急性酒精中毒,对重度酒精中毒者可明显缩短神志清醒时间并减轻酒精对肝脏的损害。

Objective To observe the effect of L-omithine-L-aspartate injection combined with naloxone in treatment of acute alcoholism. Methods 82 cases of acute alcoholism patients were randomly divided into treated group and control group. The control group received Naloxone therapy, and the treated group was given Naloxone and L-ornithine-L-aspartate injection. The therapy effect, change of liver function, time of excitation and dystaxia disappearance, and time of consciousness awakening were detected. Results Effective rate of the two groups had no significant difference （ P 〉 0.05 ）. The time of excited and dystaxia disppearance had no sig- nificant difference between mild and middle patients （ P 〉 0.05 ）. The time of consciousness awakening for severe patients in treated group was short than that in control group and there was less liver damage in treated group than that in control group（ P 〈 0.05 ）. Conclusion L-ornithine-L-aspartate injection combined with naloxone can shorten the time of consciousness awakening for severe patients, alleviate liver injury induced b alcohol, and help recover of severe patients quickly.