齐拉西酮与阿立呱唑治疗以阴性症状为主的精神分裂症对照研究

A Comparative Study of Ziprasidone and Aripiprazole in the Treatment of Schizophrenia with Predominantly Negative Symptoms

目的对比齐拉西酮和阿立呱唑治疗阴性症状为主的精神分裂症的疗效与不良反应。方法86例以阴性症状为主的精神分裂症患者随机分成两组,分别用齐拉西酮与阿立呱唑治疗8周,疗效由阳性与阴性症状量表(PANSS)、阴性症状评定量表(SANS)和临床疗效总评量表(CGI-GI)评定,副作用由副反应量表(TESS)评定。结果齐拉西酮与阿立呱唑疗效相当,对认知功能影响无显著性差异(P>0.05),齐拉西酮副反应严重程度明显低于阿立呱唑。结论齐拉西酮治疗以阴性症状为主的精神分裂症疗效确切,不良反应轻微。

Objective To compare the efficacy and side effects of Ziprasidone and Aripiprazole in the treatment of schizophrenia with predominantly negative dominantly negative symptoms were randomly divided symptoms. Methods 86 schizophrenia patients with preinto two groups and were treated with Ziprasidone and Aripiprazole for 8 weeks, respectively. The efficacies were evaluated with PANSS, SANS, CGI-GI, and the side effects were evaluated with TESS. Results Ziprasidone had the same effect as Aripiprazole, there was no significant difference in the effect on cognitive function between the two groups. Side effects of Ziprasidone were less serious than those of Aripiprazole. Conclusion Ziprasidone has clear efficacy in the treatment of schizophrenia with predominantly negative symptoms, and has light side effects.