摘要
目的研究麝冰菖喷雾剂中挥发油微乳的制备。方法采用吐温-80为表面活性剂,无水乙醇为助表面活性剂,石菖蒲挥发油作油相,借助三元相图的研究手段确定表面活性剂和助表面活性剂的最佳用量。结果吐温-80与乙醇量的比为3:1,处方量挥发油形成微乳,稳定分散于制剂中。结论通过微乳增加石菖蒲挥发油在制剂的溶解度,可提高麝冰菖喷雾剂的稳定性。
Objective To study the preparation technics of Shebingchang spray. Methods Tween-80 was used as emulsifiers, absolutealcohol as assistant emulsifiers, volatile oil fi＇om Acorus tatarinowii Schott as the oil phase, the proportion between the emulsifier and append-emulsifier was established by triangular phase diagram. Result Optimized ratio of Tween-80 and absolute aleohol was 3：1. The volatile oil in prescription formed micro-emulsions, distributing stably in the spray. Conclusion The study of micro-emulsions of volatile oil in Shebingchang spray by triangular phase diagram offered a short-cut for resolving its stability.
出处
《临床医学工程》
2009年第6期64-65,共2页
Clinical Medicine & Engineering
关键词
麝冰菖喷雾剂
挥发油
三元相图
Shebingchang spray
volatile oil
triangular phase diagram
