心病血瘀证与纤溶系统活性的相关性

Correlativity between blood-stasis syndrome in cardiopathy and activity of f ibrinolytic system

目的:从纤溶系统活性探讨心病血瘀证及其不同证型的病理机制。方法:随机选择72例心病血瘀证患者、20例心病非血瘀证患者与20例健康人,采用ELISA法检测血浆组织型纤溶酶原激活剂(t-PA)及抑制物(PAI-1)。结果:①心病血瘀证组的t-PA显著低于健康对照组和心病非血瘀证组(P<0.01),PAI-1、PAI-1/t-PA显著高于健康对照组和心病非血瘀证组(P<0.01)。②心病血瘀证不同证型组的t-PA均较健康对照组显著降低(P<0.01),PAI-1、PAI-1/t-PA均较健康对照组显著增高(P<0.05或P<0.01)。结论:纤溶系统活性降低是心病血瘀证形成的重要因素。综合分析t-PA、PAI-1、PAI-1/t-PA的水平对心病血瘀证的诊断有一定意义。

Objective： To explore the pathologic mechanism of blood-stasis syndrome in cardiopathy （BSSC） and its different syndrome types from the activity of fibrinolytic system. Methods： 72 cases with BSSC, 20 cases with non-blood-stasis syndrome in cardiopathy （NBSSC） were observed at random, 20 healthy cases as control. The levels of tissue-plasminogen activator （t-PA） and plasminogen activator inhibitor-1 （PAl-1） in blood plasma were detected by ELISA. Results： ①The level of t-PA in the group of BSSC was significantly lower than that in the groups of healthy control and NBSSC （P 〈 0.01）, and the levels of PAI-1 and PAI-1/t-PA were significantly higher than those in the groups of healthy control and NBSSC （P 〈 0.01）. ②The level of t-PA in different syndrome type groups in patients with BSSC was significantly lower than that in the healthy control group （P〈0.01）, and the levels of PAI-1,PAI-1/t-PA were significantly higher than those in the healthy control group （P 〈 0.05 or P 〈 0.01）. Conclusion： The decrease of the activity of fibrinolytic system was the important factor in the formation of BSSC. It was thought that the synthetic analysis of the levels of t-PA, PAI-1 and PAl-1/t-PA had some value for the diagnosis of B SSC.