摘要
目的评价不同剂量甲基强的松龙(甲强龙)治疗重症哮喘的效果。方法将60例重症哮喘病人随机分为A、B组,分别静脉应用甲强龙40、60mg,均为每8h注射1次,平均治疗3～5d,观察两组病人的临床疗效、肺功能改善及并发症情况。结果两组治疗前后最大呼气流量、用力肺活量、一秒钟用力呼气容积差异有显著性(t=10.74～19.65,P均<0.01);两组间治疗效果比较差异无显著性(H=0.068,P>0.05);B组并发症明显多于A组,差异有显著性(χ2=11.52,P<0.05)。结论甲强龙40mg,每8h注射1次治疗重症哮喘病人较为适宜。
Objective To evaluate the efficacy of different dosages of methylprednisolone in the therapy of severe asthma. Methods Sixty patients with severe asthma were randomly divided into groups A and B. They were given intravenous methylprednisolone 40 and 60 mg, respectively, every 8 h, with an average of 3-5 days. The clinical effects, improvement of lung function and complications were observed. Results The maximal expiratory flow, forced vital capacity, forced expiratory volume in one second showed significant differences between before and after therapy in both groups （t= 10.74-19.65 ,P〈0.01）, but the difference of efficacy between the two groups was not significant （H= 0. 068, P〉0.05）. The complications of group B were more than group A （X^2 =11.52,P〈0.05）. Conclusion Medication of intravenous methylprednisolone, 40 mg, 8-hourly, for severe asthma is reasonable.
出处
《齐鲁医学杂志》
2009年第4期353-354,共2页
Medical Journal of Qilu
关键词
哮喘
甲强龙
治疗结果
Asthma
Methylprednisolone
Treatment outcome
