血浆脑利钠肽与心力衰竭关系的临床研究

Clinical study of the relationship between heart failure and plasma brain natriuretic peptide

目的探讨血浆脑利钠肽(BNP)在心力衰竭患者体内的变化规律以及对心功能评估的价值。方法用免疫荧光法测定110例心力衰竭患者(HF组)及20例健康体检者(对照组)血浆BNP浓度;行超声心动图仪检查测定左室射血分数(LVEF)。结果HF组BNP值明显高于对照组,差异有统计学意义(P<0.01),且HF组随NYHA分级增高其BNP水平越高;心功能Ⅰ级,Ⅱ级,Ⅲ级、Ⅳ级比较,BNP水平差异均有统计学意义(P<0.01);治疗后1周BNP值同治疗前有显著降低(P<0.01);LVEF与BNP水平成负相关,血浆BNP水平较高者病死率增加。结论监测BNP水平可作为心力衰竭诊断、心功能评估以及疗效及预后的指导指标。

Objective To investigate plasma brain natriuretic peptide （BNP） in heart failure patients, as well as the changes of the value of assessment of cardiac function. Methods Measured by Immune-fluorescence assay using 110 cases of patients with congestive heart failure （ HF group） and 20 cases of healthy persons （ control group） of plasma BNP concentra- tion; use echocardiography measurement of left ventricular ejection fraction （LVEF）. Results BNP in heart failure group was significantly higher than control group, the difference was statistically significant （ P 〈 0.01 ）, and the BNP level increased with the higher the group in NYHA classification of heart failure; BNP levels have a statistically significant difference （ P 〈 0. 01 ） in 4 different groups of cardiac function; Comparison with the pre-treatment, each group＇s concentration of BNP signifi- cantly reduced after one week treatment （P 〈0.01 ） ; BNP level and LVEF was negatively correlated, and higher plasma BNP levels increase in mortality. Conclusion Monitoring BNP level can be used as the guidance indicators of diagnosis of heart failure, cardiac function assessment as well as the efficacy and prognosis.